A fatal head-on crash in Boone County Tuesday night left one woman dead and a man injured on Route E near Akeman Bridge Road.

Around 8:25 p.m., a northbound 2010 Dodge Ram 2500 crossed the center line and struck a southbound 2014 Chevrolet Cruze head-on.

The 24-year-old Harrisburg woman driving the Cruze, died at the scene; her body was later taken to the Boone County Medical Examiner’s Office.

The Dodge Ram driver, a 23-year-old man from Harrisburg, sustained moderate injuries and was hospitalized at University Hospital.

It’s unclear if he was wearing a seat belt; the woman was not.

Troop F notes this is December’s fifth fatal crash and the 50th fatality of 2025.

Next of kin have been notified.